Initially, excessive cortisol production (which can lead to insulin insensitivity, immunosuppression and the thinning of the gut lining) may result from an overactive HPA axis. Later, the body’s ability to synthesize cortisol and other steroid hormones may decrease. Ultimately, chronic stress can lead to adrenal exhaustion and low cortisol output.
ADHS nutritionally supports desired DHEA, Secretory IgA and normal cortisol levels.
ADHS supplies raw materials necessary for the synthesis of steroid hormones and epinephrine, the conversion of tyrosine to catecholamines, and hormone secretion. Nutrients required for carbohydrate metabolism and mitochondrial energy production are provided, as are nutrients needed for tissue growth and repair, including stem cell differentiation and proliferation.
Additionally, ADHS incorporates a unique blend of Chinese and Ayurvedic herbal components providing constituents shown to support normal organ function in response to stress.
NUTRITIONAL SUPPORT FOR ADRENAL FUNCTION
Amino Acids for Catecholamines
- L-tyrosine. This is the key raw material for the synthesis of norepinephrine and epinephrine.
B Complex Vitamins
Individual vitamins of the B complex work in partnership because they form coenzymes (enzyme helpers) used in energy-yielding metabolic pathways.
- Pantothenate. The adrenal glands require pantothenate for adequate steroid hormone synthesis. Pantothenate is the precursor of Coenzyme A, the coenzyme essential for metabolizing fatty acids for energy production. In addition, acetyl Coenzyme A is used as the building block for the sterol nucleus.
- Thiamine and Riboflavin. These vitamins, together with pantothenate, are needed to convert carbohydrate to acetyl Coenzyme A for energy production and for steroid synthesis.
- Niacinamide. Niacinamide forms NADH, the general electron carrier to funnel electrons into the mitochondrial electron transport chain for oxidative phosphorylation. In addition, niacinamide forms NADPH, the reducing agent needed to convert cholesterol into steroid hormones. For example, the synthesis of pregnenolone, the first steroid hormone of the pathway, employs three successive monoxygenase steps, each requiring NADPH.
- Pyridoxine HCL. This vitamin forms pyridoxal phosphate, required to break down most amino acids, and specifically to convert the amino acid tyrosine to catecholamines (aromatic amino acid decarboxylase).
Antioxidants/ reducing agents
- Vitamin E. This versatile lipid antioxidant effectively scavenges free radicals and protects membranes, including the smooth endoplasmic reticulum (where mixed function oxidases are located), from lipid peroxidation.
- Vitamin C. The concentration of vitamin C in the adrenal glands is among thehighest in the body. Vitamin C functions as a reducing agent for mixed function oxidases employed in the synthesis of steroid hormones, as well as epinephrine (tyrosine hydroxylase and dopamine hydroxylase, the first and third enzymes respectively, of the epinephrine pathway). Vitamin C also possesses antiinflammatory activity.
- Magnesium. As a cofactor for almost all reactions involving ATP, the energy currency of the cell, magnesium is particularly critical for tissues geared to the export of specific products such as hormones.
- Manganese. Manganese is a cofactor for enzymes of the citric acid cycle and the key energy-producing steps in the cell. It also supports the immune system, neuromuscular health and tissue repair.
- Copper. Copper promotes normal healing and it possesses anti-inflammatory activity. Tyrosine hydroxylase and DOPA decarboxylase require copper as a cofactor for epinephrine synthesis.
In addition to established nutrients, several herbal extracts help support normal adrenal function. Many of these have their origins in Chinese or Ayurvedic traditions.
- Cornus officinalis. Extracts of berries have been used in traditional Chinese practice. They are associated with sour, slightly warm properties. This herb is said to assist yang energy and to auguments glandular function, especially liver and kidneys. It supports collapsed qi and increases kidney yin.
- Dipsacus asper. A bitter herb used in traditional Chinese medicine to support liver and kidneys and related functions and to promote movement of blood. The herb is said to increase kidney yin energy.
- Shisandra chinensis. According to Chinese traditions, this herb is classified as warm and sour, with the ability to enrich kidney yin, to inhibit the leakage of qi and to calm the heart by balancing the yin of the heart. Extracts of Shisandra chinensis support many organ functions, including spleen and kidney, and normal homeostatic mechanisms in response to stress.
- Indian Bedellium. (Also known as Balsamodendra mukul and Commi mukul.) Resinous preparations of mukul help normal mucus secretions, and support normal gastrointestinal and immune functions.
- Gulancha tinospora. (Guduchl Tinospora, Tinospora cordifolia). Bitter extracts of this herb have been used in Ayurvedic traditions since ancient times. They are said to help balance normal immune response and to support normal blood sugar levels.
Two (2) tablets one (1) to two (2) times each day as a dietary supplement or as otherwise directed by a healthcare professional.
Vitamin C (as ascorbic acid), Vitamin E (as d-alpha tocopheryl acetate), Thiamin (B1) (as cocarboxylase chloride), Riboflavin (B2), Niacin (as niacinamide), Vitamin B6 (as pyridoxal-5-phosphate and pyridoxine HCl), Pantothenic Acid (as calcium pantothenate), Zinc (as zinc gluconate), Copper (as copper gluconate), Manganese (as manganese gluconate), L-Tyrosine, Achyranthes (Achyranthes bidentata) (root) (extract), Damiana (Turnera diffusa) (leaf) (extract), Gotu Kola (Centella asiatica) (herb) (extract), Sichuan Teasel (Dipsacus asper) (root) (whole & extract), Asiatic Dogwood (Cornus officinalis) (fruit) (extract), Basil (Ocimum baccilicum) (leaf) (extract), Schisandra (Schisandra chinensis) (fruit) (extract), Indian Tinospora (Tinospora cordifolia) (stem & root) (extract), Rubidium (from vegetable culture†).
† Specially grown, biologically active vegetable culture containing Phytochemically Bound Trace Elements™ and other phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors.
Stearic acid (vegetable source), silica, modified cellulose gum, food glaze, and magnesium stearate (vegetable source).
Not recommended for pregnant or lactating women.
KEEP OUT OF REACH OF CHILDREN.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.